Relationship between Lipid profile and Carotid artery parameters among Mgbuoba community dwellers, Port Harcourt, Nigeria: A random survey
Keywords:
Carotid artery, Lipids, Cholesterol, cIMT, Triglycerides, HDL, LDL, TC, PlaquesAbstract
Background: An important variable in apparently normal individuals that may affect findings on duplex carotid scan is their lipid numbers. In developing countries like Nigeria, routine health checks are not upheld and where available are not exhaustive. Carotid intima media thickness (cIMT) and cholesterol have been implicated as risk factors for stroke. This study seeks to assess the association between carotid parameters and lipid profile amongst apparently healthy subjects.
Method: This prospective, cross sectional, community-based study, assessed the extra-cranial common and internal carotid artery variables in 74 randomly selected apparently healthy individuals, from Mgbuoba community, Port Harcourt Rivers State. Fasting venous blood samples were collected and analysed using a Colour Spectrophotometer for Total Cholesterol (TC), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and Triglyceride (TG).
Result: Data was collected on Excel spread sheet and analyzed using SPSS 23 statistical software package. Seventy-four (74) subjects comprising 30 (41%) males and 44(59%) females respectively were studied. Their mean age ± SD was 38.60 ±12.56yrs. Mean Systolic blood ±SD and diastolic blood pressure±SD were 122.94 ± 12.64mmHg and 75.41 ± 9.20 mmHg respectively. There was negative correlation between total cholesterol and LCC PSV, negative correlation between HDL and LCC diameter and positive correlation between LDL cholesterol and IMT. On the RCC there was a negative correlation between HDL and RI.
Conclusion: The impact of cholesterol on the carotid artery parameters is not just in symptomatic or diseased states but also in apparently normal individuals. An important area would be the impact of HDL on vessel distensibility.
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