Female infertility of Endocrine Origin in Warri, Delta State, Nigeria
Keywords:Female infertility, endocrine disorders, reproductive age
Background: The causes of female infertility are multifactorial. It is essential to know the contribution of endocrine disorders to infertility in order to develop adequate care pathways for effective diagnosis and monitoring the efficacy of subsequent treatment of affected individuals. Objectives: This study evaluates the hormonal levels of women evaluated for infertility in order to determine the contribution of hormonal abnormalities to the aetiology of female factor infertility. It also correlates age of women with hormonal abnormalities with levels measured hormones. Results: Serum luteinizing hormone (LH), follicle stimulating hormone (FSH), oestrogen (E2), progesterone and prolactin were determined in 330 infertile women aged 38.8±0.5years and 100 fertile women aged 33.3±0.2years by ELISA technique using reagents supplied by Monobind Inc. USA. Hormonal disorders were detected in 130/330(39.4%) of the infertile women. The identified hormonal abnormalities were hyperprolactinaemia 30(23.7%), normo-gonadotropic-normo-oestrogen with anovulation (Poly Cystic Ovarian Syndrome) 17(13.08%), hypergonadotropic-hypogonadism 43(33.08%), increased FSH with luteal phase deficiency 16(12.31%), hypogonadotropic-hypogonadism 05(3.84%) and hypergonadotropic-hypogonadism with hyperprolactinaemia 19(14.62%). Serum LH and FSH correlated positively (p<0.005) while progesterone correlated negatively (p<0.05) with age among infertile women with hormonal abnormalities. Conclusion: The reported endocrine disorders in this study are higher than previously reported by our group in Kano, northern Nigeria. Women with infertility should be adequately evaluated in order to achieve successful treatment outcome.
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