The Impact of Chronic Alcohol Consumption on Sex Hormones and Semen Parameters in male rabbits.


  • Mathias Abiodun Emokpae University of Benin
  • Doreen O. Osabuohien Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Science, University of Benin, Benin City, Nigeria


Alcohol, testosterone, LH, FSH, fertility.


Background: It is not clear what concentration of alcohol constitutes male fertility risk.

Aim: This study evaluates the impact of chronic alcohol consumption on sex hormones and semen indices in albino rabbits fed with different concentrations of alcohol.

Materials and methods: The animals (aged 10-15 months) were divided into 5 groups of 6 animals each; groups 1, 2, 3, and 4 were fed with 4%, 12%, 20% and 40% alcohol respectively at 5ml/Kg body weight for 6weeks, while group 5 served as control. Serum sex hormones were assayed using automated chemistry analyzer (MINI VIDAS). Semen analysis histomorphological studies were done using standard methods. The means were compared using Students’ t-test and Pearson correlation was used to correlate the measured parameters with concentrations of alcohol administered.

Results: Results showed that serum testosterone, LH and FSH were significantly lower(P<0.001) in all alcohol treated groups than control. Sperm count and motility were also significantly lower (p<0.001) in all treated groups than control. Testosterone (r= -0.761, P<0.001), FSH (r = -0.775, P<0.001), LH (r= -0.778, P< 0.001), sperm count (r= -0.880, P<0.001) and motility (r= -0.911, P<0.001) correlated negatively with increasing concentrations of alcohol. The histomorphological examination of the testes and epididymis in groups 2, 3 and 4 showed moderate to severe histomorphological changes.

Conclusion: Chronic ingestion of alcohol in high percentages had deleterious effect on the male sex hormones, testes and epididymis which could affect fertility potential. A careful use of high concentrations of alcohol is suggested.

Author Biography

Mathias Abiodun Emokpae, University of Benin

Department of Medical Laboratory Science, Associate Professor


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How to Cite

Emokpae, M. A., & Osabuohien, D. O. (2020). The Impact of Chronic Alcohol Consumption on Sex Hormones and Semen Parameters in male rabbits. The Nigerian Health Journal, 18(4), 148–156. Retrieved from

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