Carbamazepine Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome

Authors

  • Ehiaghe Lonia Anaba Lagos State University Teaching Hospital, 1-5 Oba Akinjobi Way, Ikeja, Lagos, Nigeria

DOI:

https://doi.org/10.60787/tnhj.v22i4.612

Keywords:

DRESS, Carbamazepine, eosinophilia, drug reaction

Abstract

Background: Drug reaction with eosinophilia and systemic symptoms syndrome is a rare adverse, life threatening drug reaction caused by several drugs including Carbamazepine. The objective of this report is to create awareness of this life threatening reaction to a commonly prescribed drug for seizure disorders.

Methods: This is a case report of drug eosinophilia syndrome in a 33-year old female following clinical and laboratory evaluation at the skin clinic for generalized erythematous rashes following the use of Carbamazepine.

Results: She was found to have generalized, scaly, erythematous papules, patches and plagues. Laboratory results included blood eosinophilia, elevated liver enzymes and histopathology report of spongiotic dermatitis with eosinophilic infiltrates.

Conclusion: Drug reaction with eosinophilia and systemic symptoms syndrome can be caused by Carbamazepine. A diagnosis of this rare life threatening drug reaction should be suspected in patients presenting with generalized erythematous rashes following the use of Carbamazepine.

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Author Biography

Ehiaghe Lonia Anaba, Lagos State University Teaching Hospital, 1-5 Oba Akinjobi Way, Ikeja, Lagos, Nigeria

Head Of Dermatology Unit, Department Of Medicine

References

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Ksouda K, Affes H, Mahfoudh N, Chtourou L, Kammoun A, Charfi A et al. HLA-A*31:01 and carbamazepine-induced DRESS syndrom in a sample of North African population. Seizure. 2017; 53:42-46.

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Published

2023-01-07

How to Cite

Anaba, E. L. (2023). Carbamazepine Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome. The Nigerian Health Journal, 22(4), 448–451. https://doi.org/10.60787/tnhj.v22i4.612

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Section

Case Report and Series
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