The Impact of Chronic Alcohol Consumption on Sex Hormones and Semen Parameters in male rabbits.

Mathias Abiodun Emokpae

Abstract


Background: It is not clear what concentration of alcohol constitutes male fertility risk. Aim: This study evaluates the impact of chronic alcohol consumption on sex hormones and semen indices in albino rabbits fed with different concentrations of alcohol. Materials and methods: The animals (aged 10-15 months) were divided into 5 groups of 6 animals each; groups 1, 2, 3, and 4 were fed with 4%, 12%, 20% and 40% alcohol respectively at 5ml/Kg body weight for 6weeks, while group 5 served as control. Serum sex hormones were assayed using automated chemistry analyzer (MINI VIDAS). Semen analysis histomorphological studies were done using standard methods. The means were compared using Students’ t-test and Pearson correlation was used to correlate the measured parameters with concentrations of alcohol administered. Results: Results showed that serum testosterone, LH and FSH were significantly lower(P<0.001) in all alcohol treated groups than control. Sperm count and motility were also significantly lower (p<0.001) in all treated groups than control. Testosterone (r= -0.761, P<0.001), FSH (r = -0.775, P<0.001), LH (r= -0.778, P< 0.001), sperm count (r= -0.880, P<0.001) and motility (r= -0.911, P<0.001) correlated negatively with increasing concentrations of alcohol. The histomorphological examination of the testes and epididymis in groups 2, 3 and 4 showed moderate to severe histomorphological changes. Conclusion: Chronic ingestion of alcohol in high percentages had deleterious effect on the male sex hormones, testes and epididymis which could affect fertility potential. A careful use of high concentrations of alcohol is suggested.


Keywords


Alcohol, testosterone, LH, FSH, fertility.

References


Kumar P, Clark M. Alcohol. Kumar and Clark clinical medicine., W. B. Saunders, London, UK 2002: 250-1.

Chia SE, Lim ST, Tay SK, Lim ST. Factors associated with male infertility: a case control study of 218 infertile and 240 fertile men. BJOG 2000;107: 55–61.

Emokpae MA,Uadia PO, Omale- Itodo A, Orok TN. Male infertility and Endocrinopathies in Kano, North Western Nigeria. Annals Afri Med 2007; 6(2): 64- 7.

Sinclair S. Male infertility: Nutritional and Environmental considerations. Altern Med Rev 2000;5(1):28-38.

Keskin MZ, Budak S, Gubari S, Durmaz K, Yoldas M, Celik O, Aksoy EE, Libey YO. Do Cigarette and alcohol affect semen analysis? Arch Ital Urol Androl 2016; 88(1):56-9.

Parasuraman S, Raveendran R, Kesavan A. Blood sample collection in small laboratory animals. J Pharmacol Pharmacother 2010; 1(2): 87–93.

Dosumu OO, Akinola OB, Akang EN. Alcohol-induced testicular oxidative stress and cholesterol homeostasis in rats – the therapeutic potential of virgin coconut oil. Middle East Fertil Soc J. 2010;17:122–8.

Condorelli RA, Calogero AE, Vicari E, La Vignera S. Chronic consumption of alcohol and sperm parameters; our experience and the main evidences. Andrologia 2015; 47(4):368-79.

Alvarez S. Do some additions interfere with fertility? Fertil Steril 2015;103(1):22-6.

American Society for Reproductive Medicine. Infertility: an overview, a guide for patients. Fertil Steril 2013; (100)3: 3-15

Hart RJ, Doherty DA, McLanchlan RI, Walls ML, Keelan JA, Dickson JE, Skakkebaek NE, Norman RJ, Handelsman DJ. Testicular function in a birth cohort of young men. Hum Reprod 2015;30(12):2713-24.

Brugh VM, Lipshultz LI. Male factor infertility. Medical Clinics of North America. 2004;88 (2): 367–85

Pourentezari M, Talebi AR, Mangoli E, Anvari M, Rahimipour M. Addiction deleterious effects of alcohol consumption on sperm parameters and DNA intergrity in diabetic mice. Andrologia 2016;48(5):564-9.

Sharma R, Biedenharn K, Fedor J, Agarwal A. A Lifestyle factors and reproductive health: Taking control of your fertility. Reprod Biol Endocrinol 2013;11: 66.

Uadia PO, Emokpae MA. Male infertility in Nigeria: A neglected reproductive health issue requiring attention. J. Basic Clin. Reprod. Sci. 2015;4(2): 45-53

Ren J, Banan A, Keshavarzian A, Zhu Q, LaPaglia N,McNulty J. Exposure to ethanol induces oxidative damage in the pituitary gland. Alcohol 2005;35:91-101.

Martinez M, Macera S, de Assis GF, Pinheiro PFF, Almeida CCD, Tirapelli LF, et al. Structural evaluation of the effects of chronic ethanol ingestion on the testis of Calomys callosus. Tissue Cell 2009;;41:199–205.

Rooney KL, Domar AD. The impact of life-style behaviours on infertility treatment outcome. Curr Opin Obstet Gynecol 2014;26(3):181-5.

Shafi H, Esmaeilzadeh S, Delavar MA, Haydari FH, Mahdinejab N, Abedi S. Prevalence of varicocele among primary and secondary infertile men: Association with occupation, smoking and drinking alcohol. N Am J Med Sci 2014; 6(10):532-5.

Guthauser B, Boitrelle F, Plat A, Thiercelin N, Vialard F. Chronic excessive alcohol consumption and male fertility: a case report on reversible azoospermia and a literature review.AlcoholAlcohol 2014;49(1):42-4.

Osinubi A, Daramola AO, Noronha CC, Okanlawon AO, Ashiru OA. The effect of quinine and ascorbic acid on rat testes. West Afr. J. Med. 2007;26: 217–21.

Wegnerberger S, Kanuri G, Bergheim I. Alcohol drinking patterns and nutrition in Alcoholic liver disease In: Trends in Lacoholic liver disease Research-Clinical and Scientific aspects. Ichiro Shimizu (ed). In Tech publisher, Rijeka, Croatia.2012 pp.1-23.

Van Haaren MRT, Hendriks HFJ. Alkoholstoffwechsel. In: Alkohol und Alkoholfolgekrankheiten Grundlagen – Diagnostik – Therapie, Singer, M.V., Teyssen, S. Springer Berlin Heidelberg, 1999 pp.95-107.

Wang N, Tikellis G, Sun C, Pezic A, Wang L, Wells JC, Cochrane J, Ponsonby AL, Dwyer T.The effect of maternal prenatal smoking and alcohol consumption on the placenta-to-birth weight ratio.Placenta. 2014;35(7):437-441

Sohrabvand F, Jafari M, Shariat M, Haghollahi F, Lotfi M. Frequency and epidemiologic aspects of male infertility. Acta Med Iran 2015;53(4):231-235.

Alshahrani S, Agarwal A, Assidi M, Abuzenadah AM, Durairajanayagam D, Ayaz A, Sharma R, Sabanegh E. Infertile men older than 40years are at higher risk of sperm DNA damage. Reprod Biol Endocrinol 2014;12:103.doi: 10.1186/1477-7827-12-103

Suter PM. Alkohol und Ernährung. In: Alkohol und Alkoholfolgekrankheiten Grundlagen – Diagnostik – Therapie, Singer, MV, Teyssen S (ed). Springer Berlin Heidelberg 2005 pp.326-348.

Oremosu A.A, Akang EN. Impact of alcohol on male reproductive hormones, oxidative stress and semen parameters in Sprague–Dawley rats. Middle East Fertil Soc J 2014;20: 114–8.

Hoek JB, Pastorino JG. Ethanol, oxidative stress and cytokine induced liver cell injury. Alcohol 2002;27: 63–8.

Emanuele M, Tentler J, Emanuele N, Kelley M. In vivo effects of acute EtOH on rat α and β luteinizing hormone gene expression. Alcohol 1991;8: 345–8.

Sengupta S, Ray R, Shetty K, Desai N. Pituitary gonadal functioning in male alcoholics in an Indian psychiatric hospital. Alcohol 1991; 26: 47–51.

Mendelson JH, Mello NK, Ellingboe J. Effects of acute alcohol intake on pituitary–gonadal hormones in normal human males. J Pharmacol Exp Ther 1977; 202: 676–682.


Full Text: PDF

Refbacks

  • There are currently no refbacks.




Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

ISSN: 1597-4292

x
Message