Effect of Methanol Extract of Treculia Africana Seeds on Reproductive Hormones, Thyroid Stimulating Hormone and Oxidative Stress Markers in Female Wistar Rats
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Abstract
Background: Women in search for fertility have turn their way from orthodox medicine to herbal medicine in order to achieve pregnancy. The increasing infertility problem in modern society, which results in an emotional, psychological, cultural, and social burden that depletes couples. The aim of this study is to evaluate the effects of methanol extract of Treculia africana seeds on the reproductive hormones and oxidative stress markers in female Wistar.
Method: Twenty (20) animals weighing between 160g to 180g were randomly selected in 4 groups of 5 animals per group. Administration of extract was done in 21 days and on the 22nd day, the animals were sacrificed and tissues and organs harvested. Statistically, the data obtained from the findings were analyzed using ANOVA and SPSS version 23. The results were expressed in mean and standard error deviation. P<0.05 was said to be significant.
Results: There is significant increase in serum follicle stimulating hormone concentration for the medium dose extract(150mg/kg). Luteinizing hormone, estrogen significantly increases in the medium and high doses (150mg/kg and 200mg/kg), and an increase in progesterone at all doses. TSH, prolactin, total protein and final weight of the animals increase significantly. Glutathione (GSH) serum level decrease significantly for the medium dose of extract. There was a dose dependent significant decrease when compared to control for SOD and MDA and may lack antioxidant properties.
Conclusion: The extract significantly increasing reproductive hormones and thyroid stimulating hormones and may enhance breast milk production in lactating mother.
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References
1.Gbaranor KB, Tee PG, Agara HN, Victor PD, Alasia OM, David-Sarogoro N, Opusunju BH, George BO, Nonju II, Ovili-Odili BZ, Nonju TI, Nwauzoma AP, Nwosu GN. Phytochemical analysis of leaf extract of Englerina drummomdii Balle ex Polhill & Wiens. World Journal of Pharmaceutical Research. 2021;10(11):128-134.
2.Lowik AJ. The Palgrave Handbook of Critical Menstruation Studies. Sex Reprod Health Matters. 2020;28(1):1854928.
3. Gbaranor KB, Adienbo OM, Tee PG, Alasia OM, Tamuno-Opubo A, William AM, Agara HN, Amadi H, Nonju TI, Daka IR, Nonju II, Oriji EI, Nwosu GN, Emeghara GI. Effect of Englerina drummondii Balle ex Polhill & Wiens on follicle-stimulating hormone, luteinizing hormone, oestrogen, and progesterone in MSG-induced alterations in reproductive parameters in female rats. Int J Recent Innov Med Clin Res. 2021;3(4):19–25
4.Gbaranor KB, Ovili-Odili BZ, Okpara EP, Tamuno-Opubo A, Victor PD, Orupabo CD, Tee PG, Alasia OM, Sapira-Ordu L, Nonju II, Nwosu GN. Effect of hydroalcohol extract of Englerina drummondii Balle ex Polhill & Wiens (mistletoe) leaves on prolactin and thyroid stimulating hormone in female Wistar rats. Green J Med Sci. 2021;11(2):109–12.
5. Strahler J. Food cue-elicited brain potentials change throughout menstrual cycle: modulation by eating styles, negative affect, and premenstrual complaints. Horm Behav. 2020; 124:104811.
6. Wang J. Risk of multiple pregnancy when infertility is treated with ovulation induction by gonadotropins. Fertil Steril. 2003;80(3):664–5.
7. Meneses K, Holland A. Current evidence supporting fertility and pregnancy among young survivors of breast cancer. Contemp Nurse Educ. 2014;43(3):374–81
8. Ikpeze OC. Fundamentals of Obstetrics and Gynaecology. Afri Fst Publ; 2009. p. 271.
9. Akinola O, Fabanwo K, Rabiu K, Akinoso OA. Semen quality in male partners of infertile couples in Lagos, Nigeria. Int J Trop Med. 2010;5(2):37–9.
10. Redmond GP. Thyroid dysfunction and women's reproductive health. Thyroid. 2004;14(Suppl 1):S5–15
11.Krassas G, Poppe K, Glinoer D. Thyroid function and human reproductive health. Endocr Rev. 2010;31:702–55.
12. Krassas GE, Papadopoulou F, Tziomalos K, Zeginiadou T, Pontikides N. Hypothyroidism has an adverse effect on human spermatogenesis: a prospective, controlled study. Thyroid. 2008;18:1255–9.
13. Ombelet W, Cooke I, Dyer S, Serour G, Devroey P. Infertility and the provision of medical services in developing countries. Hum Reprod. 2008;14(6):605–21.
14. Tabong PT, Adongo PB. Infertility and childlessness: a qualitative study of the experiences of infertile couples in Northern Ghana. BMC Pregnancy Childbirth. 2013;13:72.
15.Dyer S. Infertility-related reproductive health knowledge and help-seeking behavior in African countries. Hum Fertil (Camb). 2008;11(1):29–33.
16. Wischmann T, Stammer H, Scherg H, Gerhard I, Verres R. Psychosocial characteristics of infertile couples: a study by the Heidelberg fertility consultation service. Hum Reprod. 2010;25(6):1753–61.
17. Ekwere P, Archibong E, Bassey E, Ekabua J, Ekanem E, Feyi W. Infertility among Nigerian couples as seen in Calabar, Port Harcourt. Afr J Reprod Health. 2007;11(2):35–40.
18. Kaur H, Rao K. Fibroids and infertility. Int J Infert Fetal Med. 2014;5(1):1–7.
19. Olayemi FO. A review on some causes of male infertility. Afr J Biotechnol. 2010;9(20):2834–42.
20. Erhirhie E, Ilodigwe E, Ajaghaku D, Mbagwu I, Moke E. Toxicity evaluation of a commercial herbal preparation commonly used in Nigeria. Eur J Med Plants. 2015;5(2):176–90.
21. Handa SS, Khanuja SPS, Longo G, Rakesh DD. Extraction technologies for medicinal and aromatic plants. Trieste: ICS UNIDO; 2008.
22. Aderibigbe AO, Adeyemi IO, Agboola OI. Central nervous system depressant properties of Treculia africana Decne. Ethnobot Leaflets. 2010; 14:108.