Biopsy-Confirmed Lupus Nephritis with Advanced Sclerosing Disease Managed with Overlap Treatment. A Case Report

Authors

  • Ogala-Akogwu VL
  • Uduagbamen P Bowen University/Bowen University Teaching Hospital, Ogbomosho
  • Galadanci H
  • Anteyi E

DOI:

https://doi.org/10.60787/tnhj.v24i2.828

Keywords:

case report, lupus nephritis, remission, relapse, histology, haemodialysis, kidney biopsy, systemic lupus erythematosus

Abstract

Background: Lupus nephritis, complicating systemic lupus erythematosus, can progress to end-stage kidney disease, with a poor prognosis. Histological diagnosis is essential in formulating an effective treatment regimen particularly with symptom overlap.

Method: We highlighted the role of a histological diagnosis in the management of Lupus nephritis with complex overlapping symptoms according to approved treatment protocol.

Result: She was anemic and the histological diagnosis was class VI lupus nephritis. She was managed using an overlapping treatment spanning classes IV – VI, with haemodialysis (HD), mycophenolate mofetil, methylprednisolone and diuretics based on heightened disease activity and extrarenal manifestations. Using the WHO and the International Society of Nephrology/Renal Pathology Society revised guidelines, KDIGO recommended haemodialysis for classes III, IV, and V with nephrotic syndrome, in addition to high dose corticosteroids, cyclophosphamide/MMF (induction therapy), and low dose corticosteroid/MMF for maintenance therapy. The disease went into remission, and she continued outpatient HD.

Conclusion: The case highlights the place of histological diagnosis in managing LN associated with complexities of staging and symptoms-overlap to achieve optimal results.

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References

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Published

2024-06-10

How to Cite

Ogala-Akogwu, V. L., Uduagbamen, P., Galadanci, H., & Anteyi, E. (2024). Biopsy-Confirmed Lupus Nephritis with Advanced Sclerosing Disease Managed with Overlap Treatment. A Case Report. The Nigerian Health Journal, 24(2), 1340 – 1344. https://doi.org/10.60787/tnhj.v24i2.828

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Section

Case Report and Series
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